ODCs

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2 OMIM references -
1 associated gene
10 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
2 associated genes
13 signs/symptoms

Fibronectin glomerulopathy

Systemic-onset juvenile idiopathic arthritis

FN1	(UniProt - OMIM)		IL6	(UniProt - OMIM)
			MIF	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	FN1	(0.63)	MIF

Citations in the biomedical literature:

Fibronectin glomerulopathy		Systemic-onset juvenile idiopathic arthritis
	Synonym(s): - GFND - Glomerulopathy with fibronectin deposits		Synonym(s): - Still disease - Systemic polyarthritis

	Classification (Orphanet): - Rare genetic disease - Rare renal disease		Classification (Orphanet): - Rare respiratory disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Diseases of the genitourinary system -		Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: childhood Average age of death: normal Type of inheritance: unknown

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references

Fibronectin glomerulopathy		Systemic-onset juvenile idiopathic arthritis
	Very frequent - Autosomal dominant inheritance - Chronic arterial hypertension - Edema of the legs / lower limbs - Functional anomalies of the kidney and the urinary tract - Hematuria / microhematuria - Nephrotic syndrome - Proteinuria - Renal failure - Renal glomerular defect / glomerulopathy Occasional - Intracranial / cerebral / meningeal hemorrhage		Very frequent - Arthritis / synovitis / synovial proliferation - Articular / joint pain / arthralgia - Autoimmunity / autoimmune reaction / autoantibodies - Biological inflammatory syndrome / increased erythrocyte sedimentation rate / CRP - Cutaneous rash - Fever / chilling - Hydrarthrosis / articular / joint effusion Frequent - Mediastinal / hilar adenopathies Occasional - Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax - Acute abdominal pain / colic - Hepatomegaly / liver enlargement (excluding storage disease) - Pericardium anomalies / pericarditis / absence / cysts / pericardial effusion - Splenomegaly